[Regional cerebral oxygen saturation in neonates with meconium aspiration syndrome].

Abstract

OBJECTIVE:

This study examined the changes of regional cerebral oxygen saturation (rSO2) by noninvasive near infrared spectrophotometry in neonates with meconium aspiration syndrome (MAS).

METHODS:

Seventy-three full neonates with MAS were divided into three groups by respiratory symptoms: asymptomatic group (group 1, n=38), common group (group 2, n=28) and severe group (group 3, n=7). Near infrared spectrophotometry was used to measure the cerebral rSO2 on days 1, 3, 5 and 7 after birth. Thirty healthy full-term newborns served as the Control group.

RESULTS:

The cerebral rSO2 of group 1 decreased significantly compared with that of the Control group between days 1 and 3 (P < 0.05). The cerebral rSO2 of group 2 or group 3 was significantly lower than that of group 1 and the Control group on days 1, 3 and 5 (P < 0.05). The MAS patients with mild hypoxic-ischemic encephalopathy (HIE) had significantly higher brain rSO2 levels than those with medium or severe HIE on days 2, 3 and 5 (P < 0.05).

CONCLUSIONS:

The cerebral rSO2 decreased in neonates with MAS. The values for rSO2 correlated with the severity of HIE in MAS patients.

• Authors: Zhi-Guang Li, Wen-Fang Ye, Fei-Qiu Wen, Hai-Shu Ding
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 8 Issue 3 Pg. 191-4 (Jun 2006) ISSN: 1008-8830 [Print] China
• PMID: 16787588 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oxygen

Topics

• Brain (metabolism)
• Female
• Humans
• Hypoxia-Ischemia, Brain (metabolism)
• Infant, Newborn
• Male
• Meconium Aspiration Syndrome (metabolism)
• Oxygen (metabolism)
• Spectroscopy, Near-Infrared