Abstract |
The present work was aimed at evaluating the in vitro effects of a lyophilized extract of wine (JW-E) obtained from Jacquez grapes (Vitis aestivalis-cinereaxVitis vinifera grapes) on the production of key molecules released in inflammatory disease utilising interleukin-1beta (IL-1beta) activated chondrocytes. The extract contains large amounts of phenolic components, in particular some flavonoids (flavan-3-ols, also known as catechins) and proanthocyanidins, as hydroxycinnamic acids and anthocyanins, that possess several biological features such as antiinflammatory and antioxidant effects and a "radical scavenger" activity too. In this study, we assayed the effect of JW-E on the production of key molecules released during chronic inflammatory events as nitric oxide (NO), prostaglandins E(2) ( PGE(2)) and reactive oxygen species (ROS) in human chondrocytes culture, stimulated with proinflammatory cytokine interleukin-1beta. The JW-E proved to possess good ability against the harmfull effects of IL-1beta. Our data showed the protective effects of JW-E in cartilage alteration, that appears greater than that elicited by indomethacin, a not steroidal antiinflammatory drug ( NSAID), commonly employed in joint diseases.
|
Authors | A M Panico, V Cardile, S Avondo, F Garufi, B Gentile, C Puglia, F Bonina, N A Santagati, G Ronsisvalle |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 13
Issue 7
Pg. 522-6
(Jul 2006)
ISSN: 0944-7113 [Print] Germany |
PMID | 16785044
(Publication Type: Journal Article)
|
Chemical References |
- Interleukin-1
- Plant Extracts
- Reactive Oxygen Species
- Nitric Oxide
- Dinoprostone
|
Topics |
- Cartilage, Articular
(cytology)
- Cells, Cultured
- Chondrocytes
(drug effects)
- Dinoprostone
(metabolism)
- Fruit
- Humans
- Inflammation
(drug therapy)
- Interleukin-1
(pharmacology)
- Nitric Oxide
(metabolism)
- Osteochondritis
(drug therapy)
- Plant Extracts
(pharmacology, therapeutic use)
- Reactive Oxygen Species
(metabolism)
- Vitis
- Wine
|