Effect of meso-dihydroguaiaretic acid from Machilus thunbergii Sieb et Zucc on MMP-1 expression in heat shock-induced cultured primary human fibroblasts.

Abstract

Ethanol and aqueous extracts of Machilus thunbergii Sieb et Zucc (Lauraceae) used traditionally for the treatment of a variety of diseases were screened in vitro for MMP-1 inhibitory actions. Meso-dihydroguaiaretic acid (MDGA) from the stem bark of M. thunbergii showed a significant inhibition of matrix metalloproteinase (MMP)-1 in primary human fibroblasts by heat shock-induced. This study investigated the effect of MDGA isolated from M. thunbergii on heat shock-induced premature skin aging. MDGA reduced the expression of MMP-1 at the protein level in a dose-dependent manner in heat shock-induced cultured primary human fibroblasts. Taken together, these results show that MDGA can prevent the harmful effects of heat (and/or IR) that lead to skin aging.

• Authors: Hyung-In Moon, Jae-Chul Jung
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 20 Issue 8 Pg. 714-6 (Aug 2006) ISSN: 0951-418X [Print] England
• PMID: 16775809 (Publication Type: Journal Article, Retracted Publication)

Chemical References

• Lignans
• Plant Extracts
• dihydroguaiaretic acid
• Guaiacol
• Matrix Metalloproteinase 1

Topics

• Cell Proliferation (drug effects)
• Cells, Cultured
• Fibroblasts (drug effects, enzymology)
• Guaiacol (analogs & derivatives, pharmacology)
• Heat-Shock Response (drug effects)
• Hot Temperature
• Humans
• Lauraceae (chemistry)
• Lignans (pharmacology)
• Matrix Metalloproteinase 1 (metabolism)
• Plant Extracts (pharmacology)