Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir.

Abstract

Tenofovir-related tubule damage characterized by Fanconi syndrome, renal insufficiency and nephrogenic diabetes insipidus has been reported in the adult HIV-infected population. To our knowledge there has been no reported case of such complications in the pediatric population. We report the case of a 12-year-old perinatally HIV-infected African-American girl who developed nephrogenic diabetes insipidus, renal insufficiency and Fanconi-like syndrome while taking tenofovir (Viread) in combination with lopinavir-ritonavir (Kaletra) and didanosine (Videx).

• Authors: Sabiha Hussain, Abeer Khayat, Asad Tolaymat, Mobeen H Rathore
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 21 Issue 7 Pg. 1034-6 (Jul 2006) ISSN: 0931-041X [Print] Germany
• PMID: 16773419 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-HIV Agents
• HIV Protease Inhibitors
• Organophosphonates
• Pyrimidinones
• Lopinavir
• Tenofovir
• Adenine
• Didanosine
• Ritonavir

Topics

• Adenine (adverse effects, analogs & derivatives)
• Anti-HIV Agents (adverse effects)
• Child
• Diabetes Insipidus, Nephrogenic (chemically induced)
• Didanosine (adverse effects)
• Drug Therapy, Combination
• Fanconi Syndrome (chemically induced)
• Female
• HIV (pathogenicity)
• HIV Infections (drug therapy, transmission)
• HIV Protease Inhibitors (adverse effects)
• Humans
• Kidney (drug effects)
• Kidney Diseases (chemically induced)
• Lopinavir
• Organophosphonates (adverse effects)
• Pregnancy
• Pregnancy Complications (drug therapy)
• Pyrimidinones (adverse effects)
• Ritonavir (adverse effects)
• Tenofovir