[The vagus-inhibiting action of alpha-endorphin].

Abstract

An intravenous bolus injection of 0.1 ml alpha-endorphin (1 x 10(-8)-1 x 10(-4) g/ml) didn't change the heart rate in frogs. The parasympathetic bradycardia induced by the peripheral vagus stimulation was decreased by alpha-endorphin. This vago-inhibitory action was dose-dependent (1 x 10(-5)-1 x 10(-4) g/ml). The maximal inhibitory action was watched in 4-8 and 9-15 minutes after bolus injection of alpha-endorphin in concentration of 1 x 10(-5) and 1 x 10(-4) g/ml accordingly.

• Authors: G E Samonina, E P Karazeeva
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 111 Issue 2 Pg. 174-5 (Feb 1991) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vagoingibiruiushchee deĭstvie al'fa-éndorfina.
• PMID: 1677295 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endorphins
• alpha-Endorphin

Topics

• Animals
• Bradycardia (etiology, physiopathology)
• Dose-Response Relationship, Drug
• Electric Stimulation
• Electrocardiography
• Endorphins (pharmacology)
• Neural Inhibition (drug effects, physiology)
• Parasympathetic Nervous System (drug effects, physiology)
• Ranidae
• Time Factors
• Vagus Nerve (drug effects, physiology)
• alpha-Endorphin