HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Atypical mannolipids characterize Thy-1-negative lymphoma mutants.

Abstract
Essentially all eukaryotic cells, including murine lymphomas, express surface proteins, such as Thy-1, which are anchored by a phosphoinositol mannolipid. Putative mannolipid anchor precursors can be detected in these cells. Six distinct Thy-1-negative lymphoma mutants lack complete mannolipids, and three mutants synthesize atypical mannolipids. The absence of complete mannolipids can account for the lack of expression of multiple mannolipid-anchored proteins and may also account for the lack of lipid anchoring in the human disease paroxysmal nocturnal hemoglobinuria. Structural information on the mannolipids of wild-type and mutant cells indicates that anchor biosynthesis in these cells may involve both transmembrane flip-flop of intermediates and a deacylation step.
AuthorsP Lemansky, D K Gupta, S Meyale, G Tucker, A M Tartakoff
JournalMolecular and cellular biology (Mol Cell Biol) Vol. 11 Issue 8 Pg. 3879-85 (Aug 1991) ISSN: 0270-7306 [Print] United States
PMID1677158 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Surface
  • Glycolipids
  • Glycosylphosphatidylinositols
  • Phosphatidylinositols
  • Thy-1 Antigens
  • Mannose
Topics
  • Animals
  • Antigens, Surface (genetics)
  • Carbohydrate Sequence
  • Cell Line
  • Glycolipids (biosynthesis, isolation & purification, metabolism)
  • Glycosylphosphatidylinositols
  • Lymphoma (genetics, immunology)
  • Mannose (isolation & purification, metabolism)
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Phosphatidylinositols (metabolism)
  • Thy-1 Antigens

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: