Duloxetine treatment of stress urinary incontinence in women: effects of demographics, obesity, chronic lung disease, hypoestrogenism, diabetes mellitus, and depression on efficacy.

Abstract

OBJECTIVE:

To identify poor responders, we evaluated the impact of demographic characteristics and comorbidities on efficacy using an integrated database including data from four large randomized controlled trials. Duloxetine has been shown to be effective in women with stress urinary incontinence (SUI).

STUDY DESIGN:

A total of 1913 women 22-83 years of age with predominant SUI (diagnosed using a validated clinical algorithm) were randomly assigned to receive placebo (n = 955) or duloxetine (n = 958) for 12 weeks. Efficacy outcome variables included a weekly incontinence episodes frequency (IEF) from patient-completed diaries, the Incontinence Quality-of-Life (I-QOL) questionnaire score, and a Patient Global Impression of Improvement rating. Subgroups selected a priori included: ethnicity, age, body mass index (BMI), chronic lung disease, hypoestrogenism, diabetes mellitus, and depression. For safety comparisons, adverse events were compared across age and ethnicity subgroups.

RESULTS:

Reduction in IEF was minimal and not significantly different between duloxetine and placebo in women with chronic lung disease. The decrease in IEF for women > or =65 years of age was slightly diminished for duloxetine and placebo groups, but the treatment differences were maintained. There was a significantly different I-QOL improvement by BMI subgroup, with greater increases in scores associated with a higher BMI (>28 kg/m2). There were no other notable subgroup impacts on efficacy.

CONCLUSIONS:

With the possible exception of chronic lung disease, no characteristic was identified that predicted a lack of treatment response with duloxetine in the treatment of women with SUI. Elderly patients may experience lower response rates to duloxetine presumably due to age related changes in the lower urinary tract.

• Authors: Lars Viktrup, Ilker Yalcin
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 133 Issue 1 Pg. 105-13 (Jul 2007) ISSN: 0301-2115 [Print] Ireland
• PMID: 16769171 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrogens
• Thiophenes
• Duloxetine Hydrochloride

Topics

• Adult
• Aged
• Aged, 80 and over
• Chronic Disease
• Comorbidity
• Controlled Clinical Trials as Topic
• Demography
• Depression (epidemiology)
• Diabetes Mellitus (epidemiology)
• Duloxetine Hydrochloride
• Estrogens (metabolism)
• Female
• Humans
• Lung Diseases (epidemiology)
• Middle Aged
• Obesity (epidemiology)
• Thiophenes (adverse effects, therapeutic use)
• Treatment Outcome
• Urinary Incontinence, Stress (drug therapy, epidemiology)