| Abstract | OBJECTIVES: To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). METHODS: Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3. RESULTS: A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients (p < 0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively. CONCLUSION: This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively. |
| Authors | Bhushan Kumar, Sunil Arora, Muthu Sendhil Kumaran, Rajesh Jain, Sunil Dogra
(Affiliation: Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. kumarbhushan at hotmail.com)
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| Journal | Indian journal of dermatology, venereology and leprology
(Indian J Dermatol Venereol Leprol)
2006 May-Jun
Vol. 72
Issue 3
Pg. 203-6
ISSN: 0378-6323 India |
| PMID | 16766834
(Publication Type: Comparative Study, Journal Article)
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| Chemical References |
- Antibodies
- Desmoglein 1
- Desmoglein 3
|
| Topics |
- Adolescent
- Adult
- Antibodies
(analysis)
- Case-Control Studies
- Child
- Cross-Sectional Studies
- Desmoglein 1
(blood, immunology)
- Desmoglein 3
(blood, immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- India
- Male
- Middle Aged
- Mouth Diseases
(etiology, immunology)
- Pemphigus
(etiology, immunology)
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