1'S-1'-acetoxychavicol acetate isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking Rev transport.

Abstract

AIDS remains a major global health concern. Despite a number of therapeutic advancements, there is still an urgent need to develop a new class of therapy for human immunodeficiency virus (HIV). Here, it was shown that 1'S-1'-acetoxychavicol acetate (ACA), a small molecular compound isolated from the rhizomes of Alpinia galanga, inhibited Rev transport at a low concentration by binding to chromosomal region maintenance 1 and accumulating full-length HIV-1 RNA in the nucleus, resulting in a block in HIV-1 replication in peripheral blood mononuclear cells. Additionally, ACA and didanosine acted synergistically to inhibit HIV-1 replication. Thus, ACA may represent a novel treatment for HIV-1 infection, especially in combination with other anti-HIV drugs.

• Authors: Ying Ye, Baoan Li
• Journal: The Journal of general virology (J Gen Virol) Vol. 87 Issue Pt 7 Pg. 2047-2053 (Jul 2006) ISSN: 0022-1317 [Print] England
• PMID: 16760408 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Benzyl Alcohols
• Gene Products, rev
• Plant Extracts
• RNA, Viral
• Terpenes
• rev Gene Products, Human Immunodeficiency Virus
• 1'-acetoxychavicol acetate

Topics

• Active Transport, Cell Nucleus (drug effects)
• Alpinia (chemistry)
• Anti-HIV Agents (isolation & purification, pharmacology)
• Base Sequence
• Benzyl Alcohols
• Cell Line
• Drug Evaluation, Preclinical
• Gene Products, rev (metabolism)
• HIV Infections (drug therapy, virology)
• HIV-1 (drug effects, genetics, physiology)
• Humans
• In Vitro Techniques
• Leukocytes, Mononuclear (drug effects, virology)
• Phytotherapy
• Plant Extracts (isolation & purification, pharmacology)
• RNA, Viral (genetics, metabolism)
• Terpenes (isolation & purification, pharmacology)
• Virus Replication (drug effects)
• rev Gene Products, Human Immunodeficiency Virus