Abstract |
The physiological function of 5-HT(7) receptors is not yet fully determined. This study was designed to characterize the involvement of 5-HT(7) receptor in rat body temperature regulation and in adrenocorticotropic hormone ( ACTH) and corticosterone secretion. In the first part of our study, acute administration of SB-269970 (0.1-1 mg/kg, i.p.), a potent and selective 5-HT(7) receptors antagonist, dose-dependently prevented 5-HT(1A/7) receptor agonist 8-OH-DPAT (0.1 mg/kg, s.c.)- induced hypothermia and when the 5-HT(1A) receptor antagonist WAY-100,635 was co-injected with SB-269970, a reduction of the latter hypothermia was obtained in an additive manner. In contrast, 1 mg/kg (i.p.) of SB-269970 failed to prevent 8-OH-DPAT (0.5 mg/kg, s.c.)-induced increase of ACTH and corticosterone plasma levels. In conclusion, the present results unveil an additive effect of both 5-HT(1A) and 5-HT(7) receptors in core body temperature regulation.
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Authors | Céline Faure, Ouissame Mnie-Filali, Hélène Scarna, Guy Debonnel, Nasser Haddjeri |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 404
Issue 1-2
Pg. 122-6
(Aug 14 2006)
ISSN: 0304-3940 [Print] Ireland |
PMID | 16759802
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phenols
- Receptors, Serotonin
- SB 269970
- Serotonin 5-HT1 Receptor Agonists
- Serotonin Antagonists
- Sulfonamides
- serotonin 7 receptor
- Receptor, Serotonin, 5-HT1A
- 8-Hydroxy-2-(di-n-propylamino)tetralin
- Corticosterone
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Topics |
- 8-Hydroxy-2-(di-n-propylamino)tetralin
(pharmacology)
- Animals
- Body Temperature
(drug effects)
- Body Temperature Regulation
(drug effects, physiology)
- Corticosterone
(blood)
- Male
- Phenols
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptor, Serotonin, 5-HT1A
(physiology)
- Receptors, Serotonin
(drug effects, physiology)
- Serotonin 5-HT1 Receptor Agonists
- Serotonin Antagonists
(pharmacology)
- Sulfonamides
(pharmacology)
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