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Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT.

Abstract
The physiological function of 5-HT(7) receptors is not yet fully determined. This study was designed to characterize the involvement of 5-HT(7) receptor in rat body temperature regulation and in adrenocorticotropic hormone (ACTH) and corticosterone secretion. In the first part of our study, acute administration of SB-269970 (0.1-1 mg/kg, i.p.), a potent and selective 5-HT(7) receptors antagonist, dose-dependently prevented 5-HT(1A/7) receptor agonist 8-OH-DPAT (0.1 mg/kg, s.c.)-induced hypothermia and when the 5-HT(1A) receptor antagonist WAY-100,635 was co-injected with SB-269970, a reduction of the latter hypothermia was obtained in an additive manner. In contrast, 1 mg/kg (i.p.) of SB-269970 failed to prevent 8-OH-DPAT (0.5 mg/kg, s.c.)-induced increase of ACTH and corticosterone plasma levels. In conclusion, the present results unveil an additive effect of both 5-HT(1A) and 5-HT(7) receptors in core body temperature regulation.
AuthorsCéline Faure, Ouissame Mnie-Filali, Hélène Scarna, Guy Debonnel, Nasser Haddjeri
JournalNeuroscience letters (Neurosci Lett) Vol. 404 Issue 1-2 Pg. 122-6 (Aug 14 2006) ISSN: 0304-3940 [Print] Ireland
PMID16759802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Phenols
  • Receptors, Serotonin
  • SB 269970
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin Antagonists
  • Sulfonamides
  • serotonin 7 receptor
  • Receptor, Serotonin, 5-HT1A
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Corticosterone
Topics
  • 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
  • Animals
  • Body Temperature (drug effects)
  • Body Temperature Regulation (drug effects, physiology)
  • Corticosterone (blood)
  • Male
  • Phenols (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Serotonin, 5-HT1A (physiology)
  • Receptors, Serotonin (drug effects, physiology)
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin Antagonists (pharmacology)
  • Sulfonamides (pharmacology)

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