[Protective activity of adsorbed D(a)PT vaccine with the acellular pertussis component and polyoxydonium].

Abstract

The introduction of the immunomodulator polyoxidonium in an amount of 0.5 Mg/ml into adsorbed D(a)PT vaccine with the acellular pertussis component leads to the preservation of the protective activity of the pertusis component, diphtheria and tetanus toxoids, as well to the 4-time decrease of the content of adsorbent (aluminium hydroxide) from 2 to 0.5 mg/ml.

• Authors: N S Zakharova, M V Britsina, M N Ozeretskovskaia, I G Bazhanova, N U Mertsalova, A V Poddubikov, E M Zaĭtsev, E V Ermolova
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2006 Mar-Apr Issue 2 Pg. 46-9 ISSN: 0372-9311 [Print] Russia (Federation)
• PMID: 16758898 (Publication Type: English Abstract, Journal Article)

Chemical References

• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Organic Chemicals
• polyoxydonium
• Aluminum Hydroxide

Topics

• Aluminum Hydroxide (administration & dosage)
• Animals
• Diphtheria (prevention & control)
• Diphtheria-Tetanus-acellular Pertussis Vaccines (administration & dosage)
• Dose-Response Relationship, Immunologic
• Guinea Pigs
• Injections, Subcutaneous
• Mice
• Organic Chemicals (administration & dosage)
• Tetanus (prevention & control)
• Vaccination
• Whooping Cough (prevention & control)