Abstract |
Excess iron deposition in tissues leads to organ dysfunction and impairment. In this study, the protective effects of farnesol (FL), an isoprenoid, against Fe-NTA (9 mg iron/kg body weight i.p.)-induced oxidative damage and early tumour promotion markers are evaluated. The pretreatment of iron-intoxicated rats with 1% and 2%/kg body weight oral dose of FL for 7 consecutive days significantly reversed the iron-induced increase in H2O2 content (P < 0.001), malondialdehyde formation, xanthine oxidase activity (P < 0.001), ornithine decarboxylase activity (P < 0.001) and 3[H] thymidine incorporation in renal DNA (P < 0.005) with simultaneous significant depletion in serum toxicity markers blood urea nitrogen (BUN) and creatinine (P < 0.001). Significant dose-dependent restoration was recorded in renal glutathione content, its dependent enzymes and other phase II metabolizing enzymes viz., catalase, glutathione-S-transferase and quinone reductase (P < 0.001) with prophylactic treatment of FL. Present results support that FL markedly lowers the oxidative damage and appearance of tumour markers, which precludes its development as a chemopreventive tool.
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Authors | Tamanna Jahangir, Tajdar Husain Khan, Lakshmi Prasad, Sarwat Sultana |
Journal | Human & experimental toxicology
(Hum Exp Toxicol)
Vol. 25
Issue 5
Pg. 235-42
(May 2006)
ISSN: 0960-3271 [Print] England |
PMID | 16758765
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Biomarkers, Tumor
- Carcinogens
- Ferric Compounds
- Farnesol
- DNA
- Hydrogen Peroxide
- Oxidoreductases
- Glutathione Transferase
- Ornithine Decarboxylase
- Glutathione
- Nitrilotriacetic Acid
- ferric nitrilotriacetate
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Biomarkers, Tumor
- Blood Urea Nitrogen
- Carcinogens
(toxicity)
- DNA
(metabolism)
- Farnesol
(pharmacology)
- Ferric Compounds
(toxicity)
- Glutathione
(metabolism)
- Glutathione Transferase
(metabolism)
- Hydrogen Peroxide
(metabolism)
- Kidney
(drug effects, metabolism)
- Lipid Peroxidation
(drug effects)
- Male
- Microsomes
(drug effects, metabolism)
- Nitrilotriacetic Acid
(analogs & derivatives, toxicity)
- Ornithine Decarboxylase
(metabolism)
- Oxidative Stress
(drug effects)
- Oxidoreductases
(metabolism)
- Rats
- Rats, Wistar
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