[In vitro effects of antiviral drugs on the reproduction of highly pathogenic influenza A/H5N1 virus strains that induce epizooty among poultry in the summer of 2005].

Commercial drugs, such as rimantadine, amantadine, rivabirine, and arbidole, are effective in suppressing the in vitro reproduction of highly pathogenic avian influenza A/H5N1 viruses. The study has used a porcine embryonic renal cell line and the highly pathogenic A/Duck/Novosibirsk/56/05 (H5N1) strain from a sick domestic duck (Anas platyrhynchos domesticus) (Chany Lake environs, Novosibirsk Region).
AuthorsD K L'vov, I T Fediakina, M Iu Shchelkanov, A G Prilipov, P G Deriabin, G A Galegov
JournalVoprosy virusologii (Vopr Virusol) 2006 Mar-Apr Vol. 51 Issue 2 Pg. 20-2 ISSN: 0507-4088 [Print] Russia (Federation)
PMID16756173 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • Indoles
  • Rimantadine
  • Ribavirin
  • arbidol
  • Amantadine
  • Amantadine (pharmacology)
  • Animals
  • Animals, Domestic
  • Antiviral Agents (pharmacology)
  • Cell Line
  • Disease Outbreaks
  • Dose-Response Relationship, Drug
  • Ducks
  • Indoles (pharmacology)
  • Influenza A Virus, H5N1 Subtype (drug effects, physiology)
  • Influenza in Birds (epidemiology, virology)
  • Kidney
  • Microbial Sensitivity Tests
  • Poultry
  • Ribavirin (pharmacology)
  • Rimantadine (pharmacology)
  • Siberia (epidemiology)
  • Swine
  • Virus Replication (drug effects)

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