Yuexiandajisu D, a novel 18-nor-rosane-type dimeric diterpenoid from Euphorbia ebracteolata Hayata.

Abstract

Yuexiandajisu D, a novel 18-nor-rosane-type dimeric diterpenoid, was isolated from the roots of Euphorbia ebracteolata Hayata. Its structure was elucidated as 6,3':7,2'-diepoxy-di-2,3-dihydroxy-18-nor-ros-1(10),2,4,15-tetraene by spectroscopic techniques (HSQC, HMBC, DQF-COSY, TOCSY, NOESY) and chemical methods. Yuexiandajisu D showed moderate cytotoxic activity against cancer cell lines on HCT-8 and Bel-7402, with IC50 values of 2.66 and 3.76 microM, respectively.

• Authors: Guang-Miao Fu, Hai-Lin Qin, Shi-Shan Yu, Bo-Yang Yu
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) 2006 Jan-Mar Vol. 8 Issue 1-2 Pg. 29-34 ISSN: 1028-6020 [Print] England
• PMID: 16753779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• Yuexiandajisu D

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Euphorbia (chemistry)
• Humans
• Molecular Structure
• Plant Roots (chemistry)