Safety and efficacy of conservative management in acute severe pancreatitis.

Abstract	Acute severe pancreatitis represents a disease with multiple complications and a high mortality rate. The clinical evolution is related to the acute systemic inflammatory response syndrome, due mainly to inflammatory mediators and pancreatic enzymes and to the infectious complications representing a peak in the incidence of death. This study aims to retrospectively analyse the outcome of patients diagnosed with acute severe pancreatitis, conservatively treated versus those surgically managed. This study includes 151 patients, each having been diagnosed with acute severe pancreatitis (CT using Balthazar's) distributed in term of age, sex and severity parameters. The conservative treatment has included antibiotics, and anti-inflammatory drugs. The imaging and biological parameters were further statistically analysed. The clinical-biological evolution has been paralleled by the CT severity index. The conservatively treated group had a better clinical-biological outcome (p<0.05), when compared with the surgically treated group. Morbidity was significantly higher in the group exposed to surgical treatment. Conservative treatment should be the first option in acute severe pancreatitis management.
Authors	L P Lefter, Elena Dajbog, V Scripcariu, Cr Dragomir
Journal	Chirurgia (Bucharest, Romania : 1990) (Chirurgia (Bucur)) 2006 Mar-Apr Vol. 101 Issue 2 Pg. 135-9 ISSN: 1221-9118 [Print] Romania
PMID	16752678 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Bacterial Agents Anti-Inflammatory Agents, Non-Steroidal Histamine H2 Antagonists
Topics	Adult Anti-Bacterial Agents (therapeutic use) Anti-Inflammatory Agents, Non-Steroidal (therapeutic use) Drug Therapy, Combination Female Histamine H2 Antagonists (therapeutic use) Humans Male Middle Aged Pancreatectomy Pancreatitis, Acute Necrotizing (diagnosis, diet therapy, surgery, therapy) Retrospective Studies Sensitivity and Specificity Severity of Illness Index Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!