Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE.

Abstract

A case of a girl who presented at age 12 years with idiopathic cold urticaria is described. Her reactions to the cold became progressively more severe over a period of approximately 2 years, despite therapy with H1 antagonists and a type 1 receptor for cysteinyl leukotrienes receptor antagonist. She began to experience systemic symptoms on immersion in ocean water. She was atopic and had moderate persistent asthma. A trial of anti-IgE resulted in complete resolution of her urticaria and its associated manifestations. These findings should prompt a reexamination of the potential pathogenetic role played by IgE and its high-affinity receptor on mast cells in idiopathic cold urticaria.

• Authors: Joshua A Boyce
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 117 Issue 6 Pg. 1415-8 (Jun 2006) ISSN: 0091-6749 [Print] United States
• PMID: 16751006 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies, Anti-Idiotypic
• anti-IgE antibodies
• Immunoglobulin E

Topics

• Anaphylaxis (diagnosis, immunology, therapy)
• Antibodies, Anti-Idiotypic (therapeutic use)
• Child
• Cold Temperature (adverse effects)
• Diagnosis, Differential
• Female
• Humans
• Immunoglobulin E (immunology)
• Urticaria (diagnosis, immunology, therapy)