Abstract |
An autopsy case of malignant islet cell tumor of the pancreas is presented. The patient, a 64-year-old woman showed severe hypoglycemia as the initial symptom, and hyperinsulinemia was demonstrated by laboratory examinations. Metastatic tumors in the liver were found by abdominal computed tomography. Autopsy revealed a tumor measuring 6.5 x 3 x 2 cm occupying the pancreas from the body to the tail. From the results of histological and immunohistochemical studies, this was diagnosed as a malignant islet cell tumor producing multiple hormones such as insulin, glucagon, somatostatin and pancreatic polypeptide, as well as expressing the tumor-related antigens CEA and CA19-9. These findings suggested that the tumor cells showed differentiation to both endocrine cells and pancreatic duct cells.
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Authors | K Arihiro, K Inai |
Journal | Acta pathologica japonica
(Acta Pathol Jpn)
Vol. 41
Issue 2
Pg. 150-7
(Feb 1991)
ISSN: 0001-6632 [Print] Australia |
PMID | 1675032
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antigens, Tumor-Associated, Carbohydrate
- Carcinoembryonic Antigen
- Insulin
- Somatostatin
- Pancreatic Polypeptide
- Glucagon
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Topics |
- Adenoma, Islet Cell
(metabolism, pathology)
- Antigens, Tumor-Associated, Carbohydrate
(metabolism)
- Autopsy
- Carcinoembryonic Antigen
(metabolism)
- Female
- Glucagon
(metabolism)
- Humans
- Immunohistochemistry
- Insulin
(metabolism)
- Middle Aged
- Pancreatic Neoplasms
(metabolism, pathology)
- Pancreatic Polypeptide
(metabolism)
- Somatostatin
(metabolism)
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