Abstract | BACKGROUND: METHODS: Using unconditional logistic regression models, we compared quartiles of consumption for several specific antioxidants and phytoestrogens among 802 adult glioma cases and 846 controls from two study series from the San Francisco Bay Area Adult Glioma Study, 1991-2000, controlling for vitamin supplement usage, age, socioeconomic status, gender, ethnicity and total daily calories. For cases, dietary information was either self-reported or reported by a proxy. For controls, dietary information was self-reported. Gender- and series-specific quartiles of average daily nutrient intake, estimated from food-frequency questionnaires, were computed from controls. RESULTS: Significant p-values (trend test) were evaluated using significance levels of either 0.05 or 0.003 (the Bonferroni corrected significance level equivalent to 0.05 adjusting for 16 comparisons). For all cases compared to controls, statistically significant inverse associations were observed for antioxidant index (p < 0.003), carotenoids (alpha- and beta-carotene combined, p < 0.05), daidzein (p = 0.003), matairesinol (p < 0.05), secoisolariciresinol (p < 0.003), and coumestrol (p < 0.003). For self-reported cases compared to controls, statistically significant inverse associations were observed for antioxidant index (p < 0.05) and daidzein (p < 0.05). CONCLUSION:
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Authors | Nicole Tedeschi-Blok, Marion Lee, Jennette D Sison, Rei Miike, Margaret Wrensch |
Journal | BMC cancer
(BMC Cancer)
Vol. 6
Pg. 148
(Jun 03 2006)
ISSN: 1471-2407 [Electronic] England |
PMID | 16749939
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Phytoestrogens
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Topics |
- Adult
- Aged
- Antioxidants
(pharmacology)
- Brain Neoplasms
(epidemiology, prevention & control)
- Case-Control Studies
- Diet
- Female
- Glioma
(epidemiology, prevention & control)
- Humans
- Male
- Middle Aged
- Nutritional Status
- Oxidative Stress
- Phytoestrogens
(pharmacology)
- Regression Analysis
- San Francisco
(epidemiology)
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