A single oral dosage of 100, 200 or 300 mg
Epanolol or placebo was administered in a randomized double-blind, cross-over fashion to 12 patients with stable effort angina. Symptom limited bicycle ergometer tests were performed before and 2 and 8 hours after each
drug administration. Spontaneous diurnal and day to day differences in exercise tolerance and related analyzed variables were not present; 48 hours after
drug intake a carry-over effect of the previous
Epanolol administration could not be demonstrated. At each dose level of
Epanolol, 2 hours after
drug intake, heart rate and rate pressure product at peak exercise fell while exercise duration rose significantly. After 8 hours these effects were less marked. No significant differences between the 3 dose levels were found. In the pooled data of the 3
Epanolol doses, systolic blood pressure at peak exercise and maximal ischemic ST segment depression during exercise were also significantly reduced after 2 hours, while total performed external work rose. The percentage increase in heart rate during exercise after
Epanolol administration was similar to the control tests at lower exercise levels but was less marked during the later stages of the test. Heart rate after
Epanolol intake was percentage wise more reduced at higher exercise levels. Plasma levels of
Epanolol were lower 8 hours after
drug administration than after 2 hours. There was no correlation between plasma levels of
Epanolol and the observed changes of any of the exercise variables 2 hours after
drug intake.