Abstract | OBJECTIVE: Atherosclerotic lesions have regions that are hypoxic. Because the lesion contains macrophages that are loaded with lipid, we investigated whether hypoxia can influence the accumulation of lipids in these cells. METHODS AND RESULTS: CONCLUSIONS: The results demonstrate that exposure of human macrophages to hypoxia causes an accumulation of triglyceride-containing cytosolic lipid droplets. This indicates that the hypoxia present in atherosclerotic lesions can contribute to the formation of the lipid-loaded macrophages that characterize the lesion and to the accumulation of triglycerides in such lesions.
|
Authors | Pontus Boström, Björn Magnusson, Per-Arne Svensson, Olov Wiklund, Jan Borén, Lena M S Carlsson, Marcus Ståhlman, Sven-Olof Olofsson, Lillemor Mattsson Hultén |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 26
Issue 8
Pg. 1871-6
(Aug 2006)
ISSN: 1524-4636 [Electronic] United States |
PMID | 16741148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Lipoproteins, LDL
- Membrane Proteins
- PLIN2 protein, human
- Perilipin-2
- RNA, Messenger
- Triglycerides
- oxidized low density lipoprotein
- Stearoyl-CoA Desaturase
- Acyl-CoA Dehydrogenase
- Coenzyme A Ligases
|
Topics |
- Acyl-CoA Dehydrogenase
(antagonists & inhibitors)
- Cells, Cultured
- Coenzyme A Ligases
(antagonists & inhibitors)
- Cytosol
(metabolism)
- Foam Cells
(metabolism, pathology)
- Humans
- Hypoxia
(metabolism, pathology)
- Immunoblotting
- Lipid Metabolism
(drug effects)
- Lipoproteins, LDL
(pharmacology)
- Macrophages
(metabolism, pathology)
- Membrane Proteins
(genetics, metabolism)
- Perilipin-2
- RNA, Messenger
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Stearoyl-CoA Desaturase
(metabolism)
- Time Factors
- Triglycerides
(metabolism)
|