Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension.

Abstract

PURPOSE:

This report describes treatment with epidural dextran-40 and paramethasone injection of postural headache resulting from spontaneous intracranial hypotension in a pregnant patient.

CLINICAL FEATURES:

A 39-yr-old pregnant woman consulted the pain clinic for the assessment of a debilitating postural headache which was non-responsive to conventional analgesic treatment. Clinical findings and cranial magnetic resonance imaging indicated the diagnosis of spontaneous intracranial hypotension syndrome. Treatment with an epidural blood patch was not undertaken for several reasons. A lumbar epidural injection with dextran-40 and paramethasone led to a significant improvement in the symptoms and allowed a progressive discontinuation of adjuvant treatment with oral steroids, with complete resolution of symptoms.

CONCLUSION:

We report a case of spontaneous intracranial hypotension in a pregnant patient successfully treated by epidural injection of dextran-40 and paramethasone, with adjuvant oral steroid therapy. Clinical trials are warranted to establish the efficacy of this treatment as an alternative to the epidural blood patch administration.

• Authors: Ivan Bel, Luis-Alfonso Moreno, Carmen Gomar
• Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie (Can J Anaesth) Vol. 53 Issue 6 Pg. 591-4 (Jun 2006) ISSN: 0832-610X [Print] United States
• PMID: 16738294 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Dextrans
• Plasma Substitutes
• Paramethasone

Topics

• Adult
• Analgesia, Epidural
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Dextrans (administration & dosage, therapeutic use)
• Female
• Headache (drug therapy, etiology, pathology)
• Humans
• Intracranial Hypotension (complications, drug therapy, pathology)
• Magnetic Resonance Imaging
• Paramethasone (administration & dosage, therapeutic use)
• Plasma Substitutes (administration & dosage, therapeutic use)
• Pregnancy