Ring chromosome 7 with amplification of 7q sequences in a pediatric case of hepatosplenic T-cell lymphoma.

Abstract

Hepatosplenic T-cell lymphoma is rare, and most cases that have been reported with cytogenetic abnormalities have an isochromosome 7q with or without trisomy 8. A 7-year-old boy who had hepatomegaly and splenomegaly was diagnosed with hepatosplenic T-cell lymphoma on the basis of a bone marrow biopsy. The karyotype of the lymphoma cells at diagnosis included a ring chromosome 7 and trisomy 8. Fluorescence in situ hybridization analysis with chromosome 7 probes demonstrated amplification of a 7q31 sequence in the ring chromosome. While isochromosome 7q is a common abnormality in hepatosplenic T-cell lymphoma, and other structurally abnormal chromosomes 7 have been reported in a small number of cases, this is the first reported case of ring chromosome in hepatosplenic T-cell lymphoma.

• Authors: Shashirekha Shetty, Adnan Mansoor, Birgitte Roland
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 167 Issue 2 Pg. 161-3 (Jun 2006) ISSN: 0165-4608 [Print] United States
• PMID: 16737917 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Bone Marrow (pathology)
• Child
• Chromosomes, Human, Pair 7 (ultrastructure)
• Chromosomes, Human, Pair 8
• Hepatomegaly
• Humans
• Liver Neoplasms (diagnosis, genetics, pathology)
• Lymphoma, T-Cell (diagnosis, genetics, pathology)
• Male
• Ring Chromosomes
• Splenic Neoplasms (diagnosis, genetics, pathology)
• Splenomegaly
• Trisomy