Abstract | RATIONALE: METHODS: This was a retrospective study conducted at the pediatric epilepsy clinic of our university hospital. Children less than 18-years of age with epileptic encephalopathy were included in the study. Clobazam was introduced as add-on therapy, starting with 5 mg/Kg/day and increased in minimally effective doses, up to the maximum tolerated dose. Data were obtained from clinical files and follow-up visits. RESULTS: Ninety-seven patients were included in the study (39 girls), aged between 1 and 17-years-old (mean = 9.9). Twenty-six patients had Lennox-Gastaut syndrome, seven had myoclonic astatic epilepsy, nine had West syndrome and, in 57 patients, the type of epileptic encephalopathy could not be determined. Clobazam dosage ranged from 5 to 60 mg/day (mean = 37.5 mg/day). Forty (41%) patients presented with adverse events, most of which were mild and transitory, and clobazam needed to be withdrawn in only 11 patients. Nine (9.2%) patients were seizure-free after clobazam adjunctive therapy. In 11 (11.3%) patients seizure improvement was >75%, in 16 (16.5%) it was >50%, in 17 (17.5%) improvement was <50% and in 44 (45.5%) there was no change in seizure frequency. Three patients were lost to follow-up. In 85% of the patients with seizure improvement, the results lasted for more than one year. CONCLUSION:
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Authors | Rosana Carvalho Silva, Maria Augusta Montenegro, Carlos A M Guerreiro, Marilisa M Guerreiro |
Journal | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
(Can J Neurol Sci)
Vol. 33
Issue 2
Pg. 209-13
(May 2006)
ISSN: 0317-1671 [Print] England |
PMID | 16736732
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Benzodiazepines
- Clobazam
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Topics |
- Adolescent
- Anticonvulsants
(administration & dosage, adverse effects)
- Benzodiazepines
(administration & dosage, adverse effects)
- Brain
(abnormalities, drug effects, physiopathology)
- Child
- Child, Preschool
- Clobazam
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Resistance
(physiology)
- Drug Synergism
- Electroencephalography
(drug effects)
- Epilepsies, Myoclonic
(drug therapy, physiopathology, prevention & control)
- Epilepsy
(drug therapy, physiopathology, prevention & control)
- Female
- Humans
- Infant
- Male
- Nervous System Malformations
(complications)
- Patient Dropouts
(statistics & numerical data)
- Retrospective Studies
- Spasms, Infantile
(drug therapy, physiopathology, prevention & control)
- Treatment Outcome
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