The effect of the beta-emitting yttrium-90 citrate on the dose-response of dicentric chromosomes in human lymphocytes: a basis for biological dosimetry after radiosynoviorthesis.

Abstract

The production of dicentric chromosomes in human lymphocytes by beta-particles of yttrium-90 (Y-90) was studied in vitro to provide a basis of biological dosimetry after radiosynoviorthesis (RSO) of persistent synovitis by intra-articular administration of yttrium-90 citrate colloid. Since the injected colloid may leak into the lymphatic drainage exposing other parts of the body to radiation, the measurement of biological damage induced by beta-particles of Y-90 is important for the assessment of radiation risk to the patients. A linear dose-response relationship (alpha = 0.0229 +/- 0.0028 dicentric chromosomes per cell per gray) was found over the dose range of 0.2176-2.176 Gy. The absorbed doses were calculated for exposure of blood samples to Y-90 activities from 40 to 400 kBq using both Monte Carlo simulation and an analytical model. The maximum low-dose RBE, the RBE(M) which is equivalent to the ratio of the alpha coefficients of the dose-response curves, is well in line with published results obtained earlier for irradiation of blood of the same donor with heavily filtered 220 kV X-rays (3.35 mm copper), but half of the RBE(M) relative to weakly filtered 220 kV X-rays. Therefore, it can be concluded that for estimating an absorbed dose during RSO by the technique of biological dosimetry, in vitro and in vivo data for the same radiation quality are necessary.

• Authors: E Schmid, H-J Selbach, M Voth, J Pinkert, F J Gildehaus, R Klett, M Haney
• Journal: Radiation and environmental biophysics (Radiat Environ Biophys) Vol. 45 Issue 2 Pg. 93-8 (Jul 2006) ISSN: 0301-634X [Print] Germany
• PMID: 16733726 (Publication Type: Journal Article)

Chemical References

• Citrates
• Organometallic Compounds
• Radiopharmaceuticals
• yttrium citrate

Topics

• Beta Particles
• Chromosome Aberrations (radiation effects, statistics & numerical data)
• Citrates (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Dose-Response Relationship, Radiation
• Humans
• In Vitro Techniques
• Injections, Intra-Articular
• Lymphocytes (radiation effects)
• Male
• Monte Carlo Method
• Organometallic Compounds (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Radionuclide Imaging
• Radiopharmaceuticals (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Relative Biological Effectiveness
• Synovitis (diagnostic imaging, radiotherapy)
• X-Rays