Abstract |
In this study, we found that two amino acids reacted with 2,5-hexanedione to form new reaction products in vitro, respectively. In the reaction of beta-alanine and 2,5-hexanedione, a reaction product was obtained and analyses of obtained results showed it was 3-(2,5-dimethyl-1H-pyrrol-1-yl)propanoic acid; in the reaction of glycine and 2,5-hexanedione, a reaction product was also obtained and analyses showed it was (2,5-dimethyl-1H-pyrrol-1-yl)acetic acid. Two reaction products were found to be oxidized easily; in addition, the latter was more easily to be oxidized than the former in the air. Our discoveries demonstrated that reactions between amino acids and 2,5-hexanedione could exist possibly in vitro. At present, it is clear that 2,5-hexanedione causes either axon atrophy or swelling, but the underlying molecular mechanism is still unclear. Since both beta-alanine and glycine are considered as neurotransmitter in the central nervous system, the reaction products remain to be identified in vivo.
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Authors | W Pei, J Misumi, N Kubota, M Morikawa, N Kimura |
Journal | Amino acids
(Amino Acids)
Vol. 32
Issue 2
Pg. 261-4
(Feb 2007)
ISSN: 0939-4451 [Print] Austria |
PMID | 16733615
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids
- Amino Acids, Essential
- Hexanones
- Neurotoxins
- Neurotransmitter Agents
- beta-Alanine
- 2,5-hexanedione
- Glycine
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Topics |
- Amino Acids
(chemistry)
- Amino Acids, Essential
(chemistry)
- Glycine
(chemistry, metabolism)
- Hexanones
(chemistry, pharmacology)
- Kinetics
- Magnetic Resonance Spectroscopy
- Models, Chemical
- Neurotoxins
- Neurotransmitter Agents
(metabolism)
- Protein Binding
- Spectrophotometry
- beta-Alanine
(chemistry, metabolism)
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