HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Two new reactive targets of 2,5-hexanedione in vitro - beta-alanine and glycine.

Abstract
In this study, we found that two amino acids reacted with 2,5-hexanedione to form new reaction products in vitro, respectively. In the reaction of beta-alanine and 2,5-hexanedione, a reaction product was obtained and analyses of obtained results showed it was 3-(2,5-dimethyl-1H-pyrrol-1-yl)propanoic acid; in the reaction of glycine and 2,5-hexanedione, a reaction product was also obtained and analyses showed it was (2,5-dimethyl-1H-pyrrol-1-yl)acetic acid. Two reaction products were found to be oxidized easily; in addition, the latter was more easily to be oxidized than the former in the air. Our discoveries demonstrated that reactions between amino acids and 2,5-hexanedione could exist possibly in vitro. At present, it is clear that 2,5-hexanedione causes either axon atrophy or swelling, but the underlying molecular mechanism is still unclear. Since both beta-alanine and glycine are considered as neurotransmitter in the central nervous system, the reaction products remain to be identified in vivo.
AuthorsW Pei, J Misumi, N Kubota, M Morikawa, N Kimura
JournalAmino acids (Amino Acids) Vol. 32 Issue 2 Pg. 261-4 (Feb 2007) ISSN: 0939-4451 [Print] Austria
PMID16733615 (Publication Type: Journal Article)
Chemical References
  • Amino Acids
  • Amino Acids, Essential
  • Hexanones
  • Neurotoxins
  • Neurotransmitter Agents
  • beta-Alanine
  • 2,5-hexanedione
  • Glycine
Topics
  • Amino Acids (chemistry)
  • Amino Acids, Essential (chemistry)
  • Glycine (chemistry, metabolism)
  • Hexanones (chemistry, pharmacology)
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Neurotoxins
  • Neurotransmitter Agents (metabolism)
  • Protein Binding
  • Spectrophotometry
  • beta-Alanine (chemistry, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: