Idiopathic eosinophilia associated with portal vein and massive thrombosis: successful thrombolysis with streptokinase.

Portal vein thrombosis in adults is usually related to cirrhosis. There are several possible therapies. including anticoagulation, transjugular intrahepatic portosystemic shunt, balloon dilatation, local and systemic fibrinolytics agents. Hypercoagulable states are also reported in association with this disease entity. Eosinophilia may activate platelets and promote thrombosis due to proteins contained in intracytoplasmic granules, such as eosinophil cationic protein and major basic protein. There is only one paper in the medical literature linking eosinophilia and portal vein thrombosis.
We present here the case of a middle-age woman with idiopathic eosinophilia and acute portal vein thrombosis with massive venous thrombosis, involving the mesenteric, splenic, inferior cava, iliac and femoral veins, successfully treated with systemic streptokinase.
Acute portal vein thrombosis with associated mesenteric and splenic vein thrombosis is a potentially lethal coagulation disorder that can be treated successfully with systemic streptokinase.
AuthorsJesús Monterrubio Villar, Alberto Córdoba López, Anselmo J Macayo Sánchez
JournalMedical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 12 Issue 6 Pg. CS53-6 (Jun 2006) ISSN: 1234-1010 [Print] Poland
PMID16733488 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Streptokinase
  • Budd-Chiari Syndrome (drug therapy, etiology, radiography)
  • Eosinophilia (complications)
  • Female
  • Humans
  • Middle Aged
  • Portal Vein (pathology)
  • Streptokinase (therapeutic use)
  • Thrombolytic Therapy
  • Tomography, X-Ray Computed
  • Treatment Outcome

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