Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma.

To evaluate how functional disability impacts on health related quality of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at 1 year post-surgery.
Survey of extremity STS patients pre-surgery and one-year post-treatment.
100 participants who were treated for extremity STS between 2001 and 2003 at four Canadian hospitals. Patients were over 16 years, non-metastatic at diagnosis, and had limb salvage surgery.
Musculoskeletal Tumor Society Rating Scale (MSTS), a measure of impairment; Toronto Extremity Salvage Score (TESS), a measure of activity limitations; Reintegration to Normal Living Index (RNL), a measure of participation restrictions; and EQ-VAS, a measure of HRQOL.
After adjusting for demographic and clinical variables, impairment explained 54%, activity limitations explained 48%, and participation restrictions explained 61% of the variation in HRQOL. After adjustment, when all three functional measures were included in the model, only participation restrictions had a significant impact on HRQOL explaining 63% of the variation.
Impairment and activity limitations affect the daily activities a patient can perform, but it is the restriction in participation of life roles and situations that has the greatest effect on patient's HRQOL.
AuthorsDaphne Schreiber, Robert S Bell, Jay S Wunder, Brian O'Sullivan, Robert Turcotte, Bassam A Masri, Aileen M Davis
JournalQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (Qual Life Res) Vol. 15 Issue 9 Pg. 1439-46 (Nov 2006) ISSN: 0962-9343 [Print] Netherlands
PMID16732468 (Publication Type: Journal Article)
  • Activities of Daily Living
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Canada
  • Databases, Factual
  • Disability Evaluation
  • Female
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Postoperative Period
  • Quality of Life
  • Sarcoma (classification, psychology, surgery)
  • Severity of Illness Index
  • Surveys and Questionnaires

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: