Abstract |
Twenty-one patients with anorexia nervosa and 35 normal-weight patients with bulimia underwent a series of CSF studies involving measurement of CSF dynorphin A 1-8 immunoreactivity during hospitalization in an eating-disorder treatment and research program. The control group consisted of 17 healthy volunteers. There were no statistically significant differences in CSF dynorphin A 1-8 measurements among groups or within a group at various stages of treatment. These results regarding dynorphin A 1-8 immunoreactivity are discussed in light of other evidence for altered opiate function in some eating-disorder patients.
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Authors | M D Lesem, W H Berrettini, W H Kaye, D C Jimerson |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 29
Issue 3
Pg. 244-52
(Feb 01 1991)
ISSN: 0006-3223 [Print] United States |
PMID | 1673064
(Publication Type: Journal Article)
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Chemical References |
- Endorphins
- Peptide Fragments
- Receptors, Opioid
- Dynorphins
- dynorphin (1-8)
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Topics |
- Adult
- Anorexia Nervosa
(cerebrospinal fluid, diagnosis, psychology)
- Body Weight
(physiology)
- Brain
(physiopathology)
- Bulimia
(cerebrospinal fluid, diagnosis, psychology)
- Dynorphins
(cerebrospinal fluid)
- Endorphins
(physiology)
- Female
- Humans
- Peptide Fragments
(cerebrospinal fluid)
- Psychiatric Status Rating Scales
- Receptors, Opioid
(physiology)
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