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Measurement of CSF dynorphin A 1-8 immunoreactivity in anorexia nervosa and normal-weight bulimia.

Abstract
Twenty-one patients with anorexia nervosa and 35 normal-weight patients with bulimia underwent a series of CSF studies involving measurement of CSF dynorphin A 1-8 immunoreactivity during hospitalization in an eating-disorder treatment and research program. The control group consisted of 17 healthy volunteers. There were no statistically significant differences in CSF dynorphin A 1-8 measurements among groups or within a group at various stages of treatment. These results regarding dynorphin A 1-8 immunoreactivity are discussed in light of other evidence for altered opiate function in some eating-disorder patients.
AuthorsM D Lesem, W H Berrettini, W H Kaye, D C Jimerson
JournalBiological psychiatry (Biol Psychiatry) Vol. 29 Issue 3 Pg. 244-52 (Feb 01 1991) ISSN: 0006-3223 [Print] United States
PMID1673064 (Publication Type: Journal Article)
Chemical References
  • Endorphins
  • Peptide Fragments
  • Receptors, Opioid
  • Dynorphins
  • dynorphin (1-8)
Topics
  • Adult
  • Anorexia Nervosa (cerebrospinal fluid, diagnosis, psychology)
  • Body Weight (physiology)
  • Brain (physiopathology)
  • Bulimia (cerebrospinal fluid, diagnosis, psychology)
  • Dynorphins (cerebrospinal fluid)
  • Endorphins (physiology)
  • Female
  • Humans
  • Peptide Fragments (cerebrospinal fluid)
  • Psychiatric Status Rating Scales
  • Receptors, Opioid (physiology)

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