Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis.

Abstract

BACKGROUND:

The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis.

OBJECTIVE:

To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR).

PATIENTS:

Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years.

METHODS:

An open-label, randomized, parallel-group, "real-life" study design was used. Patients received mometasone furoate nasal spray once daily or nedocromil sodium nasal spray 3 times daily starting 2 to 4 weeks before the pollen season and continuing for up to 4 months. Instructions regarding the use of additional medications were given. Diary cards recording symptoms, use of medication, and adverse events were kept by the patients.

RESULTS:

All 61 patients completed the study. The prophylactic use of mometasone furoate vs nedocromil sodium led to significantly more days without symptoms (75.1% vs 54.5%; P < .001). The mometasone furoate group also had lower nasal symptom scores (mean, 1.4 vs 2.9; median, 0 vs 2; P < .001) and was more satisfied (93.1% vs 43.5%; P < .001). No serious adverse event was recorded, and there was no difference between the treatments in any adverse event.

CONCLUSIONS:

Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.

• Authors: Constantinos Pitsios, Dimitrios Papadopoulos, Evangelia Kompoti, Emmanouel Manoussakis, Viktor Garris, Konstantinos Petalas, Ioannis Tassios, Nikolaos Baibas, Kalliopi Kontou-Fili, Photini Saxoni-Papageorgiou, Nikolaos G Papadopoulos
• Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (Ann Allergy Asthma Immunol) Vol. 96 Issue 5 Pg. 673-8 (May 2006) ISSN: 1081-1206 [Print] United States
• PMID: 16729779 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Allergic Agents
• Pregnadienediols
• Mometasone Furoate
• Nedocromil

Topics

• Administration, Intranasal
• Adolescent
• Adult
• Anti-Allergic Agents (administration & dosage)
• Child
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Mometasone Furoate
• Nedocromil (administration & dosage)
• Pregnadienediols (administration & dosage)
• Rhinitis, Allergic, Seasonal (prevention & control)