Stimulation of the rat's sciatic nerve regeneration by local treatment with Xymedon.

Abstract

1. The possibility of a neuro-protective effect of Xymedon as a pharmacological stimulator of nerve regeneration has been studied through Schwann cells (SCs) located in the potential area of regenerating nerve fibers' growth. 2. Xymedon was injected into the silicone chamber connecting the central and peripheral stumps of the rat's sciatic nerve. Carboxymethyl cellulose was used as a depositioned medium. 3. A 0.95% concentration of Xymedon increased the sciatic nerve functional index (SFI) values on the 14th, 21st and 28th day after the operation. By day 30, the total number of survival neurons in the L5 dorsal root ganglion (DRG) on the ipsilateral side increased with the following changes in Xymedon concentration: [see text] The number of surviving sensory neurons in the group with 0.95% Xymedon increased by 36% (p < 0.05) compared with animals with depositioned medium but Xymedon free. 4. It is suggested that the positive effects of Xymedon on neural regeneration and recovery of motor function support the potential use of Xymedon for the treatment of peripheral nerve injuries.

• Authors: Ruslan Masgutov, Ivan Raginov, Galina Fomina, Maria Kozlova, Yuri Chelyshev
• Journal: Cellular and molecular neurobiology (Cell Mol Neurobiol) 2006 Oct-Nov Vol. 26 Issue 7-8 Pg. 1413-21 ISSN: 0272-4340 [Print] United States
• PMID: 16729249 (Publication Type: Journal Article)

Chemical References

• Neuroprotective Agents
• Pyrimidines
• xymedon

Topics

• Animals
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Injections, Intralesional
• Male
• Myelin Sheath (metabolism)
• Nerve Regeneration (drug effects)
• Neuroprotective Agents (administration & dosage, pharmacology)
• Pyrimidines (administration & dosage, pharmacology)
• Rats
• Sciatic Nerve (drug effects, injuries, metabolism, physiology)