Regional mapping of the parathyroid hormone gene (PTH) by cytogenetic and molecular studies.

Abstract

The locus for the human parathyroid hormone gene (PTH) was assigned to a region proximal to 11p15.4 using restriction fragment length polymorphisms and gene dose studies performed on a patient with the Beckwith-Wiedemann syndrome accompanied with a chromosome abnormality [46,XX,-14,+der(14),t(14;11)(q32.3;p15.3)pat]. Our data suggest that PTH is localized in 11p15.3----p15.1, most likely near the border of the bands 11p15.4 and 11p15.3.

• Authors: H Tonoki, K Narahara, T Matsumoto, N Niikawa
• Journal: Cytogenetics and cell genetics (Cytogenet Cell Genet) Vol. 56 Issue 2 Pg. 103-4 ( 1991) ISSN: 0301-0171 [Print] Switzerland
• PMID: 1672845 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Parathyroid Hormone

Topics

• Beckwith-Wiedemann Syndrome (genetics)
• Blotting, Southern
• Chromosome Aberrations
• Chromosome Mapping
• Chromosomes, Human, Pair 11
• Female
• Humans
• Infant
• Karyotyping
• Male
• Parathyroid Hormone (genetics)
• Polymorphism, Restriction Fragment Length