Abstract |
As most of hereditary spherocytosis-affected individuals experience jaundice at birth, it seemed of interest to evaluate the proportion of hereditary spherocytosis in 402 severely jaundiced neonates with a bilirubinemia level prompting phototherapy. Red cell dehydration, a hallmark of spherocytosis whether constitutional or acquired, was demonstrated in 74 of them, among whom 23 disclosed a typical pattern of spherocytosis upon red cell deformability studies. Acquired spherocytosis of immune origin was diagnosed in 19/23 and hereditary spherocytosis in 4, making the proportion of hereditary spherocytosis-affected individuals among a severely jaundiced population of neonates amount to 1%, an incidence at least 30-fold that of the overall population.
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Authors | Véronique Saada, Thérèse Cynober, Yves Brossard, Pierre Olivier Schischmanoff, Alfred Sender, Henri Cohen, Jean Delaunay, Gil Tchernia |
Journal | Pediatric hematology and oncology
(Pediatr Hematol Oncol)
2006 Jul-Aug
Vol. 23
Issue 5
Pg. 387-97
ISSN: 1521-0669 [Electronic] England |
PMID | 16728359
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Case-Control Studies
- Erythrocyte Deformability
- Erythrocytes, Abnormal
(pathology)
- Female
- France
(epidemiology)
- Hemoglobins
(analysis)
- Humans
- Incidence
- Infant, Newborn
- Jaundice, Neonatal
(epidemiology, etiology)
- Male
- Prospective Studies
- Spherocytosis, Hereditary
(complications, epidemiology)
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