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Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp.

Abstract
A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.
AuthorsGeorge R Pettit, Jiang Du, Robin K Pettit, Linda A Richert, Fiona Hogan, Venugopal J R V Mukku, Michael S Hoard
JournalJournal of natural products (J Nat Prod) Vol. 69 Issue 5 Pg. 804-6 (May 2006) ISSN: 0163-3864 [Print] United States
PMID16724845 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • 3-(hydroxyacetyl)indole
  • Anti-Bacterial Agents
  • Aza Compounds
  • Dipeptides
  • Indoles
  • Peptides, Cyclic
  • Quinones
  • Sch 538415
  • cyclo(prolyl-leucyl)
  • cyclo(prolyl-valyl)
Topics
  • Amino Acid Sequence
  • Animals
  • Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
  • Aza Compounds (chemistry, isolation & purification, pharmacology)
  • Dipeptides (isolation & purification)
  • Drug Screening Assays, Antitumor
  • Humans
  • Indoles (chemistry, isolation & purification, pharmacology)
  • Leukemia P388
  • Manitoba
  • Mice
  • Molecular Structure
  • Peptides, Cyclic (isolation & purification)
  • Quinones (chemistry, isolation & purification, pharmacology)
  • Streptococcus (drug effects)
  • Streptomyces (chemistry, isolation & purification)
  • Tumor Cells, Cultured

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