Abstract |
A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.
|
Authors | George R Pettit, Jiang Du, Robin K Pettit, Linda A Richert, Fiona Hogan, Venugopal J R V Mukku, Michael S Hoard |
Journal | Journal of natural products
(J Nat Prod)
Vol. 69
Issue 5
Pg. 804-6
(May 2006)
ISSN: 0163-3864 [Print] United States |
PMID | 16724845
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- 3-(hydroxyacetyl)indole
- Anti-Bacterial Agents
- Aza Compounds
- Dipeptides
- Indoles
- Peptides, Cyclic
- Quinones
- Sch 538415
- cyclo(prolyl-leucyl)
- cyclo(prolyl-valyl)
|
Topics |
- Amino Acid Sequence
- Animals
- Anti-Bacterial Agents
(chemistry, isolation & purification, pharmacology)
- Aza Compounds
(chemistry, isolation & purification, pharmacology)
- Dipeptides
(isolation & purification)
- Drug Screening Assays, Antitumor
- Humans
- Indoles
(chemistry, isolation & purification, pharmacology)
- Leukemia P388
- Manitoba
- Mice
- Molecular Structure
- Peptides, Cyclic
(isolation & purification)
- Quinones
(chemistry, isolation & purification, pharmacology)
- Streptococcus
(drug effects)
- Streptomyces
(chemistry, isolation & purification)
- Tumor Cells, Cultured
|