Bioactive secolignans from Peperomia dindygulensis.

Abstract

Thirteen secolignans, including eight new ones (1-8), were isolated from the EtOAc extract of Peperomia dindygulensis. The structures were mainly elucidated by 1D and 2D NMR and MS experiments, the relative configurations were determined by NOE correlations, and the absolute configurations were established by the optical rotations and CD spectra. Cytotoxicity and MDR (multidrug resistance) reversal activity of the isolated compounds were examined. Compounds 6 and 7, peperomins B (10) and E (12), showed moderate to strong growth inhibitory activity against a malignant lung tumor cell (VA-13) with IC(50) values of 15.2, 13.5, 13.9, and 1.93 microM, respectively, and also inhibited the growth of a normal lung fibroblast cell (WI-38) at the same levels. Compound 7 and peperomin E (12) exhibited inhibitory activity against a liver tumor cell (HepG2) with IC(50) values of 22.3 and 12.1 microM. Compounds 5 and 7 and peperomins A, B, C, and E (9-12) enhanced calcein accumulation in MDR 2780 cells at 25 microg/mL. Compounds 2, 3, 7, and peperomin E (12) showed inhibitory activity on induction of the intercellular adhesion molecule-1 (ICAM-1).

• Authors: Jian-Lin Wu, Na Li, Toshiaki Hasegawa, Jun-ichi Sakai, Tomokazu Mitsui, Hirotsugu Ogura, Takao Kataoka, Seiko Oka, Miwa Kiuchi, Akira Tomida, Takashi Turuo, Minjie Li, Wanxia Tang, Masayoshi Ando
• Journal: Journal of natural products (J Nat Prod) Vol. 69 Issue 5 Pg. 790-4 (May 2006) ISSN: 0163-3864 [Print] United States
• PMID: 16724842 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Lignans
• Intercellular Adhesion Molecule-1

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drug Resistance, Multiple
• Drug Screening Assays, Antitumor
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Intercellular Adhesion Molecule-1 (metabolism)
• Lignans (chemistry, isolation & purification, pharmacology)
• Molecular Structure
• Peperomia (chemistry)
• Plants, Medicinal (chemistry)