Abstract |
A new cytotoxic compound, pterocidin, was isolated from the endophytic Streptomyces hygroscopicus TP-A0451, and the structure was determined on the basis of spectroscopic data. Pterocidin showed cytotoxicity against some human cancer cell lines with IC50 values of 2.9-7.1 microM.
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Authors | Yasuhiro Igarashi, Shin-Suke Miura, Tsuyoshi Fujita, Tamotsu Furumai |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 59
Issue 3
Pg. 193-5
(Mar 2006)
ISSN: 0021-8820 [Print] England |
PMID | 16724461
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Pyrones
- pterocidin
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Topics |
- Antibiotics, Antineoplastic
(chemistry, isolation & purification, pharmacology)
- Cell Line, Tumor
- Humans
- Pyrones
(chemistry, isolation & purification, pharmacology)
- Streptomyces
(metabolism)
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