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Stem cell transplantation for polycythemia vera.

Abstract
Polycythemia vera (PV) is a rare disease in children. A 9-year-old male was diagnosed following laboratory results acquired because of an acute appendicitis. Regular phlebotomy was performed for over 2 years followed by alpha-interferon treatment. At the age of 12 years, HLA-matched unrelated stem cell transplantation including T-cell depletion was done. The conditioning regimen consisted of busulfan, cyclophosphamide, and ATG. Chimerism was monitored during the whole post-transplant period. A single dose of donor T-lymphocytes was given at month 3. One year after transplantation, chimerism was complete. The patient is in complete remission and shows no signs of transplant-related morbidity at month 78.
AuthorsHarald Reinhard, Thomas Klingebiel, Peter Lang, Peter Bader, Dietrich Niethammer, Norbert Graf
JournalPediatric blood & cancer (Pediatr Blood Cancer) Vol. 50 Issue 1 Pg. 124-6 (Jan 2008) ISSN: 1545-5017 [Electronic] United States
PMID16724311 (Publication Type: Case Reports, Journal Article)
Copyright(c) 2007 Wiley-Liss, Inc.
Topics
  • Child
  • Humans
  • Male
  • Polycythemia Vera (blood, diagnosis, therapy)
  • Stem Cell Transplantation
  • Transplantation Conditioning
  • Transplantation, Homologous

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