HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis.

Abstract
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.
AuthorsCarolina Serena, Félix Gilgado, Marçal Mariné, F Javier Pastor, Josep Guarro
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 50 Issue 6 Pg. 2240-3 (Jun 2006) ISSN: 0066-4804 [Print] United States
PMID16723595 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole
Topics
  • Amphotericin B (therapeutic use)
  • Animals
  • Antifungal Agents (therapeutic use)
  • Colony Count, Microbial (statistics & numerical data)
  • Disease Models, Animal
  • Guinea Pigs
  • Humans
  • Kidney (microbiology)
  • Liver (microbiology)
  • Microbial Sensitivity Tests
  • Mycoses (drug therapy, mortality)
  • Pyrimidines (therapeutic use)
  • Spleen (microbiology)
  • Survival Analysis
  • Triazoles (therapeutic use)
  • Trichosporon (drug effects, genetics, isolation & purification)
  • Voriconazole

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: