Abstract |
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.
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Authors | Carolina Serena, Félix Gilgado, Marçal Mariné, F Javier Pastor, Josep Guarro |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 50
Issue 6
Pg. 2240-3
(Jun 2006)
ISSN: 0066-4804 [Print] United States |
PMID | 16723595
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Pyrimidines
- Triazoles
- Amphotericin B
- Voriconazole
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Topics |
- Amphotericin B
(therapeutic use)
- Animals
- Antifungal Agents
(therapeutic use)
- Colony Count, Microbial
(statistics & numerical data)
- Disease Models, Animal
- Guinea Pigs
- Humans
- Kidney
(microbiology)
- Liver
(microbiology)
- Microbial Sensitivity Tests
- Mycoses
(drug therapy, mortality)
- Pyrimidines
(therapeutic use)
- Spleen
(microbiology)
- Survival Analysis
- Triazoles
(therapeutic use)
- Trichosporon
(drug effects, genetics, isolation & purification)
- Voriconazole
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