Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis.

We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.
AuthorsCarolina Serena, Félix Gilgado, Marçal Mariné, F Javier Pastor, Josep Guarro
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 50 Issue 6 Pg. 2240-3 (Jun 2006) ISSN: 0066-4804 [Print] United States
PMID16723595 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole
  • Amphotericin B (therapeutic use)
  • Animals
  • Antifungal Agents (therapeutic use)
  • Colony Count, Microbial (statistics & numerical data)
  • Disease Models, Animal
  • Guinea Pigs
  • Humans
  • Kidney (microbiology)
  • Liver (microbiology)
  • Microbial Sensitivity Tests
  • Mycoses (drug therapy, mortality)
  • Pyrimidines (therapeutic use)
  • Spleen (microbiology)
  • Survival Analysis
  • Triazoles (therapeutic use)
  • Trichosporon (drug effects, genetics, isolation & purification)
  • Voriconazole

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