Abstract | PURPOSE: METHODS:
Retinal photographs were graded according to the international classification. ARM was defined by the presence of late ARM (neovascular ARM, geographic atrophy) and/or soft indistinct drusen (>125 microm) and/or soft distinct drusen (>125 microm) associated with pigmentary abnormalities. Cataract classification was based on a direct standardized lens examination at the slit lamp, according to Lens Opacities Classification System III. Plasma carotenoids were measured by high-performance liquid chromatography (HPLC), in 899 subjects of the cohort. RESULTS: After multivariate adjustment, the highest quintile of plasma zeaxanthin was significantly associated with reduced risk of ARM (OR=0.07; 95% CI: 0.01-0.58; P for trend=0.005), nuclear cataract (OR=0.23; 95% CI: 0.08-0.68; P for trend=0.003) and any cataract (OR=0.53; 95% CI: 0.31-0.89; P for trend=0.01). ARM was significantly associated with combined plasma lutein and zeaxanthin (OR=0.21; 95% CI: 0.05-0.79; P for trend=0.01), and tended to be associated with plasma lutein (OR=0.31; 95% CI: 0.09-1.07; P for trend=0.04), whereas cataract showed no such associations. Among other carotenoids, only beta-carotene showed a significant negative association with nuclear cataract, but not ARM. CONCLUSIONS: These results are strongly suggestive of a protective role of the xanthophylls, in particular zeaxanthin, for the protection against ARM and cataract.
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Authors | Cécile Delcourt, Isabelle Carrière, Martine Delage, Pascale Barberger-Gateau, Wolfgang Schalch, POLA Study Group |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 47
Issue 6
Pg. 2329-35
(Jun 2006)
ISSN: 0146-0404 [Print] United States |
PMID | 16723441
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Xanthophylls
- Zeaxanthins
- beta Carotene
- Lutein
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Topics |
- Cataract
(blood, epidemiology)
- Chromatography, High Pressure Liquid
- Female
- Humans
- Lutein
(blood)
- Macular Degeneration
(blood, epidemiology)
- Male
- Middle Aged
- Risk Factors
- Xanthophylls
(blood)
- Zeaxanthins
- beta Carotene
(blood)
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