Abstract |
We report the case of a patient with hypereosinophilia and invasive thymoma harboring probable clonal proliferation of CD4+, CD8+, and CD25+ T-lymphocytes. A 64-year-old woman had eosinophilia (14.1 x 10(9)/L) and an anterior mediastinal tumor with elevated levels of serum immunoglobulin E (609.8 mg/dL) and interleukin 5 (239 pg/mL). Bone marrow aspirate showed marked infiltration by morphologically normal eosinophils with a normal karyotype but no FIP1L1-PDGFRA fusion gene. Flow cytometric analysis revealed an increasing number of CD3+/CD25+ lymphocytes in the peripheral blood, and the resected thymoma had infiltrated lymphocytes with CD4/CD8/ CD25 antigens. Moreover, the thymoma had T-cell receptor rearrangements with a cytogenetically clonal nature, ie, t(2;4)(p22;q26). Although the number of patients with thymoma showing hypereosinophilia is small, this case suggests that a subset of patients with thymoma may have clonal expansion of T-lymphocytes with abnormal phenotypes that affect clinical manifestations, including hypereosinophilia.
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Authors | Masahiko Sumi, Kosuke Nunoda, Tomonori Mizutani, Yuko Ishii, Akihiko Gotoh, Yukihiko Kimura, Yasuhiro Suga, Tatsuo Ohira, Kuniharu Miyajima, Hiromi Serizawa, Kiyoshi Mukai, Harubumi Kato, Kazuma Ohyashiki |
Journal | International journal of hematology
(Int J Hematol)
Vol. 83
Issue 3
Pg. 243-6
(Apr 2006)
ISSN: 0925-5710 [Print] Japan |
PMID | 16720555
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antigens, CD
- Oncogene Proteins, Fusion
- mRNA Cleavage and Polyadenylation Factors
- FIP1L1-PDGFRA fusion protein, human
- Receptor, Platelet-Derived Growth Factor alpha
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Topics |
- Antigens, CD
(biosynthesis)
- Cell Proliferation
- Eosinophilia
(blood, complications, genetics, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Middle Aged
- Oncogene Proteins, Fusion
- Receptor, Platelet-Derived Growth Factor alpha
- T-Lymphocytes
(metabolism, pathology)
- Thymoma
(blood, complications, genetics, pathology)
- Thymus Neoplasms
(blood, complications, genetics, pathology)
- mRNA Cleavage and Polyadenylation Factors
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