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Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort.

Abstract
Association between myosin IXB (MYO9B) gene variants and celiac disease (CD) has been reported in a study of a Dutch cohort. Six single nucleotide polymorphisms (SNPs) within the 3' part of the MYO9B gene showed significant genetic association and formed an associated haplotype. The current study aimed to replicate these findings in a Swedish/Norwegian cohort. Genotyping of the three SNPs which tagged the associated haplotype was performed in a CD family dataset (n = 326) and in an additional set of healthy controls (n = 562). Although our material provided reasonable power to detect the previously observed association, we were unable to replicate association with these SNPs. Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. Alternatively, it might be due to variable linkage disequilibria in distinct populations in the tested SNPs and a causative mutation yet to be identified or to false positive findings (type I error) in the Dutch study.
AuthorsSilja S Amundsen, Alienke J Monsuur, Martin C Wapenaar, Benedicte A Lie, Johan Ek, Audur H Gudjónsdóttir, Henry Ascher, Cisca Wijmenga, Ludvig M Sollid
JournalHuman immunology (Hum Immunol) 2006 Apr-May Vol. 67 Issue 4-5 Pg. 341-5 ISSN: 0198-8859 [Print] United States
PMID16720215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • myosin IXB
  • Myosins
Topics
  • Celiac Disease (epidemiology, genetics)
  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Linkage Disequilibrium
  • Male
  • Molecular Epidemiology
  • Myosins (genetics)
  • Norway (epidemiology)
  • Polymorphism, Single Nucleotide
  • Sweden (epidemiology)
  • White People (genetics)

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