Abstract | OBJECTIVE: To study the implications of hormone replacement therapy (HRT) treatment in the pathogenesis of Reinke's oedema (via a possible pseudo- hypothyroidism effect), and also to study why the disease affects a predominantly post-menopausal female population. DESIGN: Prospective case series study. SETTING: Two teaching hospitals and two district general hospitals in Scotland, UK. SUBJECTS: Thirty-three patients diagnosed with Reinke's oedema who presented in the out-patient department before or after treatment. RESULTS: Thyroid function tests were normal in all but two cases. Only three patients were receiving HRT treatment. CONCLUSIONS: The study produced no evidence to support a relationship between HRT treatment and the pathogenesis of Reinke's oedema; this supports previous studies which concluded that thyroid function was not related to the development of Reinke's oedema. Some new ideas regarding hormonal factors in Reinke's oedema are discussed.
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Authors | A Tsikoudas, X Kochillas, G Vernham |
Journal | The Journal of laryngology and otology
(J Laryngol Otol)
Vol. 120
Issue 10
Pg. 849-52
(Oct 2006)
ISSN: 1748-5460 [Electronic] England |
PMID | 16716238
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Adult
- Aged
- Female
- Hormone Replacement Therapy
(adverse effects)
- Humans
- Hypothyroidism
(complications)
- Laryngeal Edema
(etiology)
- Middle Aged
- Postmenopause
- Prospective Studies
- Scotland
- Smoking
(adverse effects)
- Thyroid Function Tests
- Thyroid Hormones
(metabolism)
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