[Anesthetic protection against hepatic injury].

Abstract

In this review article, hepatocyte injury by volatile anesthetics, effects of anesthetics on hepatic perfusion, protection offered by either ischemic preconditioning or anesthetic preconditioning against hepatic ischemia-reperfusion injury and effects of anesthetics on sepsis-induced hepatic injury are discussed. Halothane poses significant risk of immunologically-mediated hepatocyte injury and disturbances of hepatic blood supply. Other modern volatile anesthetics such as isoflurane, sevoflurane and desflurane seem to have only minor risks. Several animal studies demonstrate that volatile anesthetics offer more protection against ischemia-reperfusion injury than intravenous anesthetics. On the contrary, intravenous anesthetics may be more protective against sepsis-induced hepatic injury than volatile anesthetics.

• Authors: Yoshifumi Kotake
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 55 Issue 5 Pg. 570-8 (May 2006) ISSN: 0021-4892 [Print] Japan
• PMID: 16715911 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anesthetics
• Anesthetics, Intravenous
• Protective Agents

Topics

• Anesthetics (adverse effects, pharmacology)
• Anesthetics, Intravenous (pharmacology)
• Animals
• Humans
• Ischemic Preconditioning
• Liver (drug effects)
• Liver Circulation (drug effects)
• Protective Agents (pharmacology)
• Rats
• Reperfusion Injury (prevention & control)