The spectrum of orbital Rosai-Dorfman disease.

Abstract

PURPOSE:

To describe the spectrum and treatment of orbital Rosai-Dorfman disease and to review previously documented cases.

METHODS:

Retrospective, interventional case series of seven patients and literature review.

RESULTS:

Each patient with Rosai-Dorfman disease had unique disease expression requiring aggressive therapy, such as chemotherapy, radiation, and/or surgical excision. One systemically aggressive case presented with intraocular and choroidal invasion, a previously unreported finding. Response to therapy was variable and unpredictable.

CONCLUSIONS:

Rosai-Dorfman disease, although historically described as benign and self-limiting, may cause significant morbidity and mortality involving multiple organ systems. Available treatment options may not control the disease. Further research and long-term clinical correlation is necessary.

• Authors: Yasaman Mohadjer, John B Holds, Jack Rootman, Mathew W Wilson, James W Gigantelli, Philip L Custer
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2006 May-Jun Vol. 22 Issue 3 Pg. 163-8 ISSN: 0740-9303 [Print] United States
• PMID: 16714922 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Female
• Histiocytosis, Sinus (complications, diagnosis, drug therapy)
• Humans
• Male
• Middle Aged
• Orbital Diseases (complications, diagnosis, drug therapy)
• Retrospective Studies
• Tomography, X-Ray Computed