Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles.

Abstract

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 microM), A-549 cells (IC50 6.6 microM), and MES-SA cells (IC50 9.2 microM), respectively.

• Authors: Shu-Ting Huang, I-Jen Hsei, Chinpiao Chen
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 14 Issue 17 Pg. 6106-19 (Sep 01 2006) ISSN: 0968-0896 [Print] England
• PMID: 16714116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzimidazoles
• Benzothiazoles
• Benzoxazoles

Topics

• Benzimidazoles (chemical synthesis, chemistry, pharmacology)
• Benzothiazoles (chemical synthesis, chemistry, pharmacology)
• Benzoxazoles (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Humans
• Molecular Structure
• Neoplasms (drug therapy, pathology)