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An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients.

Abstract
Postprandial hyperglycemia and hyperlipidemia are considered risk factors for cardiovascular disease. This study was designed to elucidate whether improving the postprandial state by voglibose, an alpha-glucosidase inhibitor, leads to the reduction of oxidative stress markers and soluble adhesion molecules in obese type 2 diabetic patients. A total of 30 Japanese obese type 2 diabetic patients were randomly assigned and treated for 3 weeks with either diet alone (the control group) or diet plus voglibose (0.9 mg daily) (the voglibose group) (n=15 each). Analysis of the diurnal metabolic profiles revealed a significant reduction of postprandial hyperglycemia and hyperlipidemia in the voglibose group relative to the control group (P<.05), despite the similar improvement in body mass index and hemoglobin A(1c) in both groups. Voglibose also decreased significantly the plasma levels of soluble intercellular adhesion molecule 1 and urinary excretion of 8-iso-prostaglandin F(2)alpha and 8-hydroxydeoxyguanosine (P<.01) and C-reactive protein (P<.05) relative to the control group. In conclusion, this study represents the first demonstration that voglibose reduces oxidative stress generation and soluble intercellular adhesion molecule 1 in parallel with the reduction of postprandial hyperglycemia and hyperlipidemia in obese type 2 diabetic patients.
AuthorsNoriko Satoh, Akira Shimatsu, Kazunori Yamada, Megumi Aizawa-Abe, Takayoshi Suganami, Hideshi Kuzuya, Yoshihiro Ogawa
JournalMetabolism: clinical and experimental (Metabolism) Vol. 55 Issue 6 Pg. 786-93 (Jun 2006) ISSN: 0026-0495 [Print] United States
PMID16713439 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Intercellular Adhesion Molecule-1
  • Inositol
  • voglibose
Topics
  • Adult
  • Biomarkers (blood)
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Female
  • Glycoside Hydrolase Inhibitors
  • Humans
  • Hyperglycemia (drug therapy)
  • Hyperlipidemias (drug therapy)
  • Hypoglycemic Agents (administration & dosage, pharmacology)
  • Inositol (administration & dosage, analogs & derivatives, pharmacology)
  • Intercellular Adhesion Molecule-1 (blood)
  • Japan
  • Male
  • Middle Aged
  • Obesity
  • Oxidative Stress (drug effects)
  • Single-Blind Method
  • Solubility

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