Ten cases of feline mesothelioma: an immunohistochemical and ultrastructural study.

Abstract

In the cat only 10 cases of mesothelioma, mainly of the peritoneum, have been previously reported. This paper describes a further 10 cases, eight pleural and two peritoneal, in males and females aged 1-17 years. Histologically, five tumours were epithelial, three fibrosarcomatous and two biphasic. Immunohistochemical markers used in human pathology for the identification of mesotheliomas include vimentin, cytokeratin (CK) AE1/AE3, HBME-1, CK 5/6, calretinin, thrombomodulin, carcinoembryonic antigen (CEA), CD15, E-cadherin and desmin. All 10 feline mesotheliomas were positive for vimentin and CK AE1/AE3, six were positive for HBME-1, two for CK5/6, three for CEA and four for E-cadherin. All were negative for desmin and calretinin. Antibodies to thrombomodulin and CD15 failed to cross-react with feline tissues. Electron microscopy, performed in four cases, revealed microvillar structures, desmosomes and intracytoplasmic lumina, confirming its value as a diagnostic tool. The study showed that mesothelial marker antibodies commonly used in human patients can be used for the diagnosis of feline mesothelioma, preferably as a panel of antibodies rather than only one.

• Authors: B Bacci, F Morandi, M De Meo, P S Marcato
• Journal: Journal of comparative pathology (J Comp Pathol) Vol. 134 Issue 4 Pg. 347-54 (May 2006) ISSN: 0021-9975 [Print] England
• PMID: 16712862 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Animals
• Biomarkers, Tumor (analysis)
• Cat Diseases (pathology)
• Cats
• Cytoplasmic Structures (ultrastructure)
• Desmosomes (ultrastructure)
• Female
• Immunoenzyme Techniques (veterinary)
• Male
• Mesothelioma (chemistry, pathology, veterinary)
• Microscopy, Electron, Transmission (veterinary)
• Microvilli (ultrastructure)
• Peritoneal Neoplasms (chemistry, pathology, veterinary)
• Pleura (ultrastructure)
• Pleural Neoplasms (chemistry, pathology, veterinary)