Liver recipients who have
antibodies to
hepatitis B core antigen (anti-HBc) or received an anti-HBc positive liver graft are at risk of acquiring de novo
hepatitis B infection so a life long prophylaxis is required. A post-transplant vaccination against hepatitis B virus (HBV) can offer a better alternative than either
hepatitis B hyperimmune globulin (
HBIG) or
lamivudine. This study investigated the course of anti-HBs titer after vaccination and analyzed the factors that influence the response. Between October 1999 and February 2003, 37 pediatric patients were given a post-transplant vaccination when an anti-HBc positive graft was used, the recipient was anti-HBc positive, or when anti-HBs titer was below 20 IU/L irrespective of the serological status. Thirty-three patients responded to the
vaccine and did not require further
HBIG injections at a mean follow up of 33.6 months. Fifteen patients were good responder and only needed a single set of
vaccines, and 18 were poor responder needing additional boosters. Two patients developed de novo
hepatitis B infection and two required additional
HBIG injections. Preoperative severity of
liver disease, serological status of HBV of recipient or donor, use of
HBIG or pulse
steroid therapy, type of
vaccines, and dose or time interval between doses had no influence on response rate. Recipients with a high preoperative anti-HB titer, small graft-recipient weight ratio (GRWR), greater catch up growth, heavier
body weight, lower
tacrolimus level at the time of vaccination, and longer time interval between transplant or
steroid medication and vaccination yielded good response. If well tailored, post-transplant vaccination can be effective and offer patients prophylaxis against de novo
hepatitis B infection for a prolonged period of time.