Abstract |
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/ tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl- ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 mug/mL, 95% confidence interval [CI] 0.36-0.58; geometric mean avidity index 0.16, 95% CI 0.14-0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p<0.001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity.
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Authors | Nik G Johnson, Jens U Ruggeberg, Gail F Balfour, Y Chen Lee, Helen Liddy, Diane Irving, Joanna Sheldon, Mary P E Slack, Andrew J Pollard, Paul T Heath |
Journal | Emerging infectious diseases
(Emerg Infect Dis)
Vol. 12
Issue 6
Pg. 937-41
(Jun 2006)
ISSN: 1080-6040 [Print] United States |
PMID | 16707049
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Diphtheria-Tetanus-acellular Pertussis Vaccines
- Haemophilus Vaccines
- Haemophilus influenzae type b polysaccharide vaccine
- Polysaccharides, Bacterial
- Vaccines, Conjugate
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Topics |
- Antibodies, Viral
(blood)
- Antibody Affinity
- Bacterial Capsules
- Child, Preschool
- Diphtheria-Tetanus-acellular Pertussis Vaccines
(immunology)
- Haemophilus Infections
(epidemiology, immunology)
- Haemophilus Vaccines
(immunology)
- Haemophilus influenzae type b
(immunology)
- Humans
- Immunization
(methods)
- Pharynx
(virology)
- Polysaccharides, Bacterial
(immunology)
- Statistics, Nonparametric
- United Kingdom
(epidemiology)
- Vaccines, Conjugate
(immunology)
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