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Haemophilus influenzae type b reemergence after combination immunization.

Abstract
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 mug/mL, 95% confidence interval [CI] 0.36-0.58; geometric mean avidity index 0.16, 95% CI 0.14-0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p<0.001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity.
AuthorsNik G Johnson, Jens U Ruggeberg, Gail F Balfour, Y Chen Lee, Helen Liddy, Diane Irving, Joanna Sheldon, Mary P E Slack, Andrew J Pollard, Paul T Heath
JournalEmerging infectious diseases (Emerg Infect Dis) Vol. 12 Issue 6 Pg. 937-41 (Jun 2006) ISSN: 1080-6040 [Print] United States
PMID16707049 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Haemophilus influenzae type b polysaccharide vaccine
  • Polysaccharides, Bacterial
  • Vaccines, Conjugate
Topics
  • Antibodies, Viral (blood)
  • Antibody Affinity
  • Bacterial Capsules
  • Child, Preschool
  • Diphtheria-Tetanus-acellular Pertussis Vaccines (immunology)
  • Haemophilus Infections (epidemiology, immunology)
  • Haemophilus Vaccines (immunology)
  • Haemophilus influenzae type b (immunology)
  • Humans
  • Immunization (methods)
  • Pharynx (virology)
  • Polysaccharides, Bacterial (immunology)
  • Statistics, Nonparametric
  • United Kingdom (epidemiology)
  • Vaccines, Conjugate (immunology)

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