Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus.

Abstract

Myelopeptide-2 (MP-2; Leu-Val-Val-Tyr-Pro-Trp), originally isolated from the supernatant of porcine bone marrow cell culture, is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from HL-60 leukemia cells or measles virus. This effect is based on the ability of MP-2 to recover the reduced interleukin (IL)-2 synthesis and IL-2 receptor (IL-2R) expression in human T lymphocytes treated with these harmful agents. The involvement of other cytokines in MP-2 restoration of the reduced IL-2 synthesis in T lymphocytes is experimentally studied. It is shown that T helper (TH) 1 and TH2 cytokines are acting in close interaction, the character of which depends on the immune status of the T-lymphocyte donors. The data obtained allow one to suggest that the MP-2 involvement in regulatory processes is directed to the maintenance of immune homeostasis. This peptide is perspective to be applied in antitumor and antivirus therapy.

• Authors: Augusta A Mikhailova, Raissa G Belevskaya, Maria Kalyuzhnaya, Larissa A Fonina, Vsevolod A Liashenko, Rem V Petrov
• Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) (J Immunother) 2006 May-Jun Vol. 29 Issue 3 Pg. 306-12 ISSN: 1524-9557 [Print] United States
• PMID: 16699373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• Cytokines
• Interleukin-2
• Oligopeptides
• Receptors, Interleukin-2
• myelopeptides
• Interferon-gamma

Topics

• Antigens, Neoplasm (metabolism)
• Cell Proliferation
• Cytokines (metabolism)
• HL-60 Cells
• Humans
• Immune System (metabolism)
• Interferon-gamma (metabolism)
• Interleukin-2 (metabolism)
• Lymphocyte Activation
• Measles virus (metabolism)
• Neoplasms (metabolism, therapy)
• Oligopeptides (metabolism)
• Receptors, Interleukin-2 (metabolism)
• T-Lymphocytes (metabolism)