HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression of telomerase subunits in gastric cancer.

Abstract
To detect the expression of telomerase subunits (human telomerase reverse transcriptase, human telomerase associated protein 1 and human telomerase RNA) in gastric cancer and to examine the role that different telomerase subunits play in the gastric carcinogenesis, reverse transcription-polymerase chain reaction (RT-PCR) was used to detect telomerase subunits messenger RNA in 24 samples of gastric cancer and corresponding non-cancerous tissue. The results showed that the positive rate of hTERT mRNA from gastric cancer and corresponding non-cancerous tissues was 100% and 25%, respectively. The former was significantly higher than the latter (chi2 = 26.4, P < 0.01). The positive rate of hTEP1 mRNA from gastric cancer and corresponding non-cancerous tissues was 100% and 91.7%, respectively and no significant difference was found between them (chi2 = 2.1, P > 0.05). The positive rates of hTR for gastric cancer and corresponding non-cancerous tissues were both 100% and no significant difference existed between them. It is concluded that in contrast to hTEP1 and hTR, the up-regulation of hTERT mRNA expression may play a more important role in the development of gastric cancer.
AuthorsFenghua Chen, Lihua Hu, Yirong Li, Lin Wang
JournalJournal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 25 Issue 6 Pg. 741-3 ( 2005) ISSN: 1672-0733 [Print] China
PMID16696344 (Publication Type: Journal Article)
Chemical References
  • Carrier Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • TEP1 protein, human
  • telomerase RNA
  • RNA
  • TERT protein, human
  • Telomerase
Topics
  • Adult
  • Aged
  • Carrier Proteins (biosynthesis, genetics)
  • Female
  • Humans
  • Male
  • Middle Aged
  • RNA (biosynthesis, genetics)
  • RNA, Messenger (biosynthesis, genetics)
  • RNA-Binding Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stomach Neoplasms (metabolism)
  • Telomerase (biosynthesis, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: